Clinical characteristics and risk factors of 2 054 cases of mycoplasma pneumoniae pneumonia in children based on imaging and clinical severity classification

Acta Universitatis Medicinalis Anhui     font:big middle small

Found programs: Health Research Project of Anhui Province(No. AHWJ2023A30008);Basic and Clinical Col- laborative Research Enhancement Project of Anhui Medical University(No. 2020xkjT027); Research Funding for PhD Talent in the First Affiliated Hospital of Anhui Medical University(No. 1550)

Authors:Li Jiao1,2,Zhou Jiantao1,Ha Qingxu1,Huo Shaohu1,Ding Junli1,2

Keywords:children;mycoplasma pneumoniae pneumonia;severe mycoplasma pneumoniae pneumonia;imaging classification;pulmonary consolidation;co-infection;decreased breath sounds

DOI:10.19405/j.cnki.issn1000-1492.2026.01.012

〔Abstract〕 To investigate the clinical characteristics and risk factors of Mycoplasma pneumoniae pneu- monia(MPP)in children based on a dual classification integrating imaging features and clinical severity. Meth ⁃ ods Medical records of 2 054 pediatric patients with MPP were retrospectively analyzed. The cohort was stratified into severe consolidation(n=253), severe non-consolidation(n=118), non-severe consolidation(n=393), and non-severe non-consolidation groups(n=1 290)based on clinical and radiological findings. Inter group data and characteristics were compared and multiple regression analysis was conducted to construct a prediction model for se - vere consolidation group. Results Significant differences were observed among the groups in terms of age,dura-tion of fever ,length of hospital stay ,presence of pulmonary rales ,inflammatory markers[C-reactive protein (CRP)and lactate dehydrogenase(LDH)], the use of hormones,and bronchoscopic treatment(all P < 0. 05). Compared with the severe non-consolidation group , non-severe consolidation group , and non-severe non- consolidation group,children in severe consolidation group exhibited the longest duration of fever[8(6,11)days vs 6(2,9),7(6,9)and 6(3,8)days,respectively]and the longest length of hospital stay[7(5,8)days vs 6 (5,8),6(5,8)and 6(4,7)days,respectively]. They also had the highest incidence of reduced breath sounds [34 cases(13. 4%)vs 2 cases(1. 7%), 29 cases(7. 4%)and 13 cases(1. 0%), respectively]and a substan-tially higher rate of coinfections,particularly viral infections[63 cases(24. 9%)vs 23 cases(19. 5%),60 cases (15. 3%)and 190 cases(14. 7%),respectively]. Multivariate analysis indicated that the independent risk factors for severe MPP( SMPP )were age > 4. 5 years,length of hospital stay > 6. 5 days,reduced breath sounds, neutrophil-to-lymphocyte ratio(NLR )> 1. 66,LDH > 370. 5 U/L,CRP > 9. 5 mg/L,and coinfection with vi-ruses. Reduced breath sounds(OR = 5. 58,95% CI:2. 45 - 12. 69)and coinfection with bacteria(OR = 3. 11, 95% CI:1. 43 - 6. 75)were identified as the most significant risk factors for pulmonary consolidation in non-severe MPP children. Additionally,reduced breath sounds,coinfection with viruses,LDH > 365. 5 U/L,and CRP > 32. 1 mg/L were risk factors for severe pneumonia in children with pulmonary consolidation. For non-consolidation MPP children,the presence of pulmonary dry rales(OR = 2. 28,95% CI:1. 46 - 3. 56)was the primary indepen- dent risk factor for the development of severe pneumonia. Conclusion The chest imaging findings of MPP are asso- ciated with clinical severity,and the risk factor model constructed based on this imaging-clinical classification can assist in achieving precise hierarchical diagnosis and treatment in clinical practice.