〔Abstract〕 Objective To evaluate the application effect of morphology driven preparation technique in indirect restoration of posterior teeth. Methods 84 patients with dental defects were selected and divided into the control group and the experimental group randomly, with 42 patients in each group (a total of 84 teeth). Traditional preparation and morphology driven preparation techniques were used to complete dental preparation and adhesive glass ceramic restorations, respectively. The satisfaction, masticatory function, World Dental Federation (FDI) Scores for edge fracture and fixation ，edge adaptability index ，periodontal bleeding index (BI) and plaque index (PLI) of the two groups of patients were evaluated and various indicator data were recorded and statistically analyzed at 3 and 6 months after restoration completion. Results There was no statistically significant difference in satisfaction between the two groups after 3 and 6 months of repair; Both groups of data showed a significant improvement in masticatory function. There was no statistical difference after 3 and 6 months of repair. However, a statistically significant difference in masticatory function was noted after 6 months of repair compared with before and after 3 months of repair. As the repair time increased, the masticatory effect improved significantly. There was no statistically significant difference in the edge fracture and fixation index between the two groups at 3 months after repair, but there was a statistically significant difference between the two groups at 6 months with the experimental group outperforming the control group(P<0.05). The edge adaptability, BI, and PLI index were statistically significant between the two groups after 3 and 6 months of repair and the experimental group had a significant advantage (P<0.05). Conclusion Both types of tooth preparation techniques can improve patient masticatory function and reach high satisfaction after repair. However, morphology driven preparation technique has significant advantages in edge adaptability, edge fracture and fixation index scores and improve periodontal conditions. This technique is an effective method for improving dental preparation in adhesive indirect restoration of posterior teeth.