〔Abstract〕 Objective To explore the structural characteristics, biocompatibility, anti-inflammatory and antioxidant properties of hyaluronic acid (HA)/silk fibroin (SF) composite hydrogel scaffolds loaded with epigallocatechin gallate (EGCG), and to provide a new material basis for the treatment of periodontitis. Methods The composite hydrogel scaffolds were constructed by cross-linking HA and SF and loaded with EGCG. The water absorption rate, degradation property and material characteristics were detected by scanning electron microscopy. The cytocompatibility and anti-inflammatory and antioxidant properties were evaluated by in vitro experiments. Results The EGCG-loaded scaffolds exhibited a porous network structure and desirable swelling properties. In vitro experiments demonstrated that the scaffolds possessed good biocompatibility, along with the ability to inhibit the expression of inflammatory factors and scavenge reactive oxygen species. Conclusion The HA/SF-EGCG composite scaffolds have excellent biocompatibility and dual functional activities of anti-inflammatory and antioxidant, providing a new strategy for improving the clinical treatment effect of periodontitis.