〔Abstract〕 Objective To analyze the influencing factors of patients with tuberculous pleurisy complicated with pleural tuberculoma, and to provide scientific basis for the formulation of treatment plan. Methods Patients with tuberculous pleurisy were selected as the research subjects. All the subjects were divided into case group and control group according to whether they were accompanied by pleural tuberculosis tumor. Self-made questionnaires were used to collect clinical data and laboratory indicators of patients. Results A total of 276 patients with tuberculous pleurisy, with an average age of(39.22±18.12) years, were enrolled in this study, and 84 of them had complicated pleural tuberculoma. Univariate analysis showed that effusion volume, urokinase injection and glucocorticoid use were the influencing factors for the occurrence of pleural tuberculoma in patients with tuberculous pleurisy(P<0.05). Further multivariate analysis showed that pleural effusion content, urokinase injection and glucocorticoid use were statistically significant with the incidence of pleural tuberculoma in patients with tuberculous pleurisy(P=0.003,<0.001,0.001). Conclusion Pleural effusion content, urokinase injection, and the use of glucocorticoid may influence the occurrence of pleural tuberculoma in patients with tuberculous pleurisy.