〔Abstract〕 Objective To explore the potential active compounds and effect targets of Gehua Jiejiu Dizhi Decoction(GJDD) for treatment of alcoholic fatty liver disease(AFLD) based on the network pharmacology. Methods The GJDD drug-compound data set, compound-target data set and AFLD target data set were established, the "TCM-compound-target" interactive network diagram of GJDD anti-AFLD was constructed, and the network was analyzed through Cytoscape to explore GJDD potentially active compounds of anti-AFLD and their possible targets. Results GJDD might act onPIK3CA,PIK3R1,MAPK1,APPand other targets, and achieve its therapeutic purpose through multiple pathways such as inflammation-related signaling pathways, hormone-related pathways, and apoptosis-related signaling pathways. Conclusion Through network pharmacology, this study confirms the effectiveness of GJDD in the treatment of AFLD, and provides important guidance for improving the occurrence of AFLD and the research on the intervention mechanism of GJDD.