〔Abstract〕 Objective To investigate the effects of 6-gingerol on amyloid β-protein(Aβ) induced apoptosis, oxidative stress and neuroinflammation in Alzheimer's disease(AD) rats by regulating Wnt/β-catenin signaling pathway. Methods The rat model of AD was established by injecting Aβ into hippocampus of bilateral brain. The rats were randomly divided into six groups: control group, model group, low-dose 6-gingerol group, medium-dose 6-gingerol group, high-dose 6-gingerol group and positive control group. Nerve injury was evaluated by nerve injury score, brain water content was measured by dry/wet method, and hippocampal histological injury was measured by HE staining. The apoptosis of hippocampal cells was detected by flow cytometry and TUNEL staining. The protein levels of iNOS, IL-6, TNF-α, SOD, GSH-Px and MDA were detected by ELISA. The mRNA and protein relative expression levels of Wnt and β-catenin were detected by qRT-PCR and Western blot. Results Compared with the model group, after 6-gingerol treatment, nerve injury score decreased, brain water content decreased, the apoptosis rate decreased, the expression of iNOS, IL-6 and TNF-α decreased, SOD and GSH-Px protein content increased, while MDA protein content decreased. The mRNA and protein relative expression levels of Wnt and β-catenin were up-regulated. Conclusion 6-gingerol can reduce apoptosis, oxidative stress and neuroinflammation in AD rats by activating Wnt/β-catenin signaling pathway.