〔Abstract〕 Objective To compare the early osteogenesis effect of three commercialized implant surfaces SLA®,SLActive®,Xpeed®in maxillary sinus.Methods The adhesion and proliferation of MC3T3E1 cells on three titanium disks were evaluated by cell staining and CCK-8. In vivo study, 16 New Zealand rabbits were randomly divided into SLActive group and Xpeed group. Bilateral maxillary sinus external augmentation model was established. The SLA discks were used as control group, and the rest discks were implanted according to preceding group. The mRNA expression of bone morphogenetic protein 2(BMP2), core binding factor(Runx2), osteocalcin(OCN), type I collagen(COLI) were measured by qRT-PCR in 4 weeks after surgery. To evaluate their osteogenic effect, Micro CT was used to analyze the bone miner density(BMD), trabecular thickness(Tb.Th), trabecular separation(Tb.Sp) and trabecular number(Tb.N) of disk. Results The result of 6-hour cell adhesion showed no statistically significant difference in three disks, and 24-hour fluorescent staining showed that the cell morphology and spread in the Xpeed group were more sufficient than those in SLA and SLActive groups. CCK-8 test showed that cell proliferation in slactive group and Xpeed group on day 3 and 7 was higher than that in SLA group(P<0.05), there was no statistical difference between the SLActive and Xpeed groups. qRT-PCR showed that osteogenic related gene expression level in Xpeed group was higher than that in SLA and SLActive groups(P<0.01). The results of micro-CT showed that the Tb.Th, Tb.Sp of each group showed statistically significant differences(P<0.05), Tb.Th of Xpeed was larger than that of SLActive and SLA group.Tb.Sp in Xpeed was less than that in SLActive group and SLA group(P<0.05).Conclusion Which shows that Xpeed®surface has a better effect on early osteogenesis in maxillary sinus.