〔Abstract〕 Objective To explore the relationship between weight change since 20 years old and hyperuricemia(HUA) in a middle-aged Hefei population. Methods The subjects were 1 727 adults aged 45 to 60. Data was collected through face-to-face questionnaire and physical examination. The relationship between weight change since 20 year and HUA in a middle-aged Hefei population was studied by multivariate logistic regression analysis. Results After adjusting for age, education, smoking and other confounding factors, compared with men who gained<5 kg, the risk of HUA in men who gained 5-10 kg, ≥10 kg significantly increased(OR=2.12, 95%CI: 1.09-4.13,OR=2.82, 95%CI: 1.61-4.91). Compared with women who gained<10 kg, the risk of HUA in women who gained≥10 kg also significantly increased(OR=3.44, 95%CI: 1.66-7.13). Conclusion Weight gain in adulthood is associated with an increased risk of HUA, especially in men.