〔Abstract〕 Objective To explore molecular biological mechanism of Obesity Hypertension based on circNRG-1/miR-193 b-5 p/NRG-1 Axis. Methods 90 SD rats were randomly divided into three groups: control group(n=30),obese hypertension group(n=30) and NRG-1 blocker group(n=30).Blood pressure, body weight, Lee coefficient, fat coefficient, serum triglyceride and total cholesterol levels and the expression of circNRG-1/miR-193 b-5 p/NRG-1 in thoracic aorta were measured, and the expression of circNRG-1 in obese hypertensive rats was analyzed by microarray, the targeting relationship between circNRG-1 and miR-193 b-5 p was analyzed by double luciferase. Results The results of microarray showed that there were 382 circRNAs differentially expressed between the blank control group and the obese hypertension group, of which 235 were up-regulated and 147 were down-regulated(>2 times). Compared with the blank control group, the MMU-CircRNA-42742(whose paternal gene was NRG-1) was up-regulated in the obese hypertension group. Compared with the blank control group, the MMU-CircRNA-42742(paternal gene NRG-1) was up-regulated in the obese hypertension group.Compared with the blank control group, the systolic blood pressure, body weight, Lee coefficient, fat coefficient, serum triglyceride, total cholesterol, and the mRNA expression of NRG-1,circNRG-1 and miR-193 b-5 p in thoracic aorta of obese hypertensive rats all increased, and the vascular wall was proliferated and the intima was thickened. Compared with obese hypertension group, systolic blood pressure, body weight, Lee coefficient, fat coefficient, serum triglyceride, total cholesterol, mRNA expression of NRG-1,circNRG-1 and miR-193 b-5 p in thoracic aorta decreased in NRG-1 blocker group, and vascular remodeling appeared. Conclusion The expression of circNRG-1 and NRG-1 is up-regulated and the expression of miR-193 b-5 p is down-regulated in obese hypertensive rats.After blocking NRG-1,the symptoms of obese hypertensive rats improve, so circNRG-1/miR-193 b-5 p/NRG-1 axis may be a potential target for the treatment of obese hypertension.