〔Abstract〕 Objective To investigate the expression level of soluble mannose receptor(sMR) in hepatocellular carcinoma(HCC) patients and its clinical significance. Methods The serum sMR levels of patients with hepatocellular carcinoma, chronic hepatitis B(CHB) and healthy controls(HC) were detected by enzyme-linked immunosorbent assay(ELISA). The general data were collected, and the serum sMR levels in patients with different stages and pathological characteristics were compared. The ROC curve was drawn to evaluate the diagnostic efficacy of sMR and AFP for hepatocellular cancer. Results The serum sMR level of hepatocellular cancer patients was related to tumor stage, size and number. The combined diagnostic efficacy of serum sMR and AFP was significantly higher than that of a single indicator. Conclusion Serum sMR level is significantly increased in patients with hepatocellular cancer. sMR detection has important clinical significance and application value in the diagnosis of hepatocellular cancer.