〔Abstract〕 To investigate the effects of osteogenic inducer(OI) sustained-release system carried by poly(lactide-co-glycolide)(PLGA) gel on the bone remodeling of tooth extraction sockets. After tooth extraction, 27 New Zealand white rabbits were randomly divided into 3 groups: extraction sockets filled with OI sustained-release system(PLGA+OI group), extraction sockets filled with PLGA gel(PLGA group), and extraction sockets without any treatment(control group). After 2, 4, 8 weeks of tooth extraction, 3 rabbits of each group were killed and the samples of their mandibular alveolar bone were taken for radiological and histological observation. The BMD of the PLGA+OI group at 2, 4, 8 weeks was significantly higher than that of the PLGA group and control group. The variation of ABW and ABH of PLGA+OI group at 8 weeks was significantly lower than that of the PLGA group and control group(P<0.001). Histological results showed that new bone formation of the PLGA+OI group was quicker than that of the other groups. OI sustained-release system can effectively promote the bone remolding process of tooth extraction sockets and reduce the resorption of ABW and ABH, which can be a promising biomaterial for alveolar bone preservation in extraction sockets.