〔Abstract〕 Objective To elucidate the risk factors for lower extremity amputation patients of diabetic foot ulcer(DFU) disease. Methods The clinical data of 287 patients with diabetic foot ulcer based on the University of Texas(UT) wound classification system were analyzed retrospectively.Demographic characteristics, laboratory data, disease history were considered as independent variables to predict the therapeutic outcome(lower extremity amputation and non-amputation). Multivariate logistic regression was used to analyze the possible factors affecting amputation. Results The amputation rate among diabetic foot patients was 35.2%. A total of 46 variables were included in the analysis. In univariate analysis, 22 variables in the amputation group were significantly different from those in the non-amputation group(P<0.05). Binary logistic regression analysis showed that grade 2 of the UT wound classificationsystem(OR:10.090, 95%CI: 2.696-37.760,P=0.001) and grade 3(OR:35.327, 95%CI:7.648-163.678,P<0.001), ulcer history(OR:6.320, 95%CI:2.278-17.554,P<0.001), toe(OR:24.880, 95%CI:7.565-82.24,P<0.001), increased glycosylated albumin(OR:1.156,95%CI:1.040-1.284,P=0.007), elevated white blood cell count(OR:1.137, 95%CI:1.003-1.288,P=0.045) and the risk of malnutrition(OR:3.460, 95%CI: 1.348-8.878,P=0.010) were associated with increased risks from diabetic foot ulcer to amputation, while hemoglobin(OR:0.966, 95%CI: 0.941-0.991,P=0.008) was a protective factor for amputation. Conclusion For DFU patients, early treatment, control of infectionaggravation, improvement of nutritional status, and stability of short-term blood glucose are very important for the prevention of amputation.