〔Abstract〕 Objective To explore the role and mechanism of resveratrol(Res) in facial nerve injury model. Methods Male SD rats were randomly divided into sham operation group(Sham group) and facial nerve injury group(Crush group), and facial nerve injury model was established by clamping injury of right facial nerve trunk in rats of the Crush group. The rats in the Crush group were randomly divided into three groups: the control group(Crush+Vehicle group), the resveratrol group(Crush+Res group), and the inhibitor group(Crush+Res+Axitinib group). Western blot and QPCR were used to compare the expression levels of vascular endothelial growth factor b(VEGFb) and its receptors 1 and 2(VEGFR1, VEGFR2) in facial nerve of different groups. Immunohistochemistry was used to evaluate facial nerve regeneration. Results Compared with the Crush+Vehicle group, the expression of VEGFb, VEGFR1 and VEGFR2 in the Crush+Res group was increased and nerve regeneration was promoted. The expression of VEGFb, VEGFR1 and VEGFR2 in Crush+Res+Axitinib group was inhibited compared with that in Crush+Res group. Conclusion Res can enhance the expression of VEGFb, VEGFR1 and VEGFR2 after facial nerve injury and promote nerve regeneration.