〔Abstract〕 In research of dynamic monitoring of the inferior vena cava by bedside ultrasound and using the concept of optimal inferior vena cava width to guide individualized liquid therapy strategies that compared with conventional ICU fluid therapy strategies, it is studied whether it can improve the prognosis of patients with septic shock. Patients with septic shock from the Department of Critical Care Medicine of Anhui Provincial Hospital were admitted to the study. They were randomly divided into two groups by simple randomization method. The control group was treated with conventional treatment strategy while the intervention group was treated with individualized liquid management strategy.The volume and the prognosis of patients in the two groups were contrasted. There was no significant difference in gender, age, underlying disease, infection site, APACHE II score, SOFA score, and mechanical ventilation ratio between the two groups(P>0.05). The cumulative fluid intake, net fluid balance, ICU mortality and the frequency of related complications such as acute heart failure and hypoxemia in the first three and five days of the intervention group were lower than those in the control group(P<0.05).The use of an individualized liquid treatment guided by the concept of the optimal width of inferior vena cava can reduce patients' intake, reduce the risk of complications associated with fluid overload, and improve the patients' prognosis.