〔Abstract〕 58 patients with primary hepatic cancer and 24 patients with metastatic hepatic cancer were treated by transcatheter chemoembolization with drug-eluting beads microspheres. The curative effect of the two groups was evaluated by modified response evaluation criteria in solid tumors( mRECIST). The changes of liver function before and after treatment and the occurrence of postoperative complications were compared between the two groups. After a month treatment,the objective response rate( CR + PR) was 74. 14% in primary group,50. 00% in metastatic group; the disease control rate was 100. 00% and 75. 00% respectively. The difference was statistically significant( P<0. 05). The damage of liver function in the metastatic group was more serious than that in the primary group( P<0. 05). Complications were occurred in both groups. The incidence in the metastatic group was significantly higher than that in the control group. Transcatheter chemoembolization with Calli Spheres drug-eluting beads microspheres is safe and effective for hepatic cancer,and primary hepatic cancer is more accurate and safer than that of metastatic hepatic cancer.