〔Abstract〕 Objective To compare and explore dosimetric parameters of three differentradiation treatment plans and cardio-pulmonary protection for middle thoracic esophageal carcinoma. Methods A total of twenty-four patients with middle thoracicesophageal cancer were included and three radiation treatment plansfor fixed filed intensity modulated radiotherapy(IMRT), volumetric modulated arc therapy(VMAT)and tomotherapy(TOMO) were designed for each patient.Conformity index(CI), homogeneity index(HI), dosimetric parameters of organs at risk, the mean treatment time and the number of monitor units(MU) of the three plans were compared. Results Compared with VMAT and IMRT, TOMO showed better HI(P=0.01), and there was no significant difference in CI(P=0.34)among three differentradiation treatment plans,TOMO was significantly better than those of VMAT and IMRT in lung V30and V20(P<0.05); There was no statistically significant difference between TOMO and VAMT in lung V10、V5and Dmean(P>0.05), VMAT was significantly better than IMRT in lung V20、V5(P<0.05); There was no significant difference in heart V30,V40,Dmean(P>0.05) and the highest dose of spinal cord(Dmax)(P>0.05) among three plans;TOMO had the longest treatment time and the most number of MU, VMAT was the fastest to execute, with an average time reduction of 66% compared to TOMO. Conclusion In radiotherapy for middle thoracic esophageal cancer, TOMO is more advantageous than VMAT and IMRT in terms of HI and lung protection, and there is no significant difference in CI and dosimetric parameters of heart and spinal cord.TOMO requires longer treatment time and more number of MU;VMAT has the shortest treatment time and better plan quality than IMRT, so it is the most cost-effective treatment.