〔Abstract〕 Objective To investigate the changes of age-related hippocampal glutamate receptor 1 level and its correlation with spatial learning and memory ability in CD-1 mice exposed to inflammation during late pregnancy.Methods Maternal mice were intraperitoneally injected with lipopolysaccharide(LPS, 50 μg/kg) or normal saline at days 15～17 of pregnancy. Their offspring were treated as LPS group and normal saline group, and completed Morris water maze at the age of 3 months and 15 months respectively. The level of GluR1 was detected by Western blotting.Results The 15-month normal saline group(compared to the 3-month normal saline group) and the 15-month LPS group(compared to 15-month normal saline group) had longer swimming distanceand lower swimming distance percentage in the target quadrant(all P<0.05) in the Morris water maze, with statistical significance and lower hippocampal GluR1 levels( all P<0. 01). The difference had statistical significance. Correlation analysis showed that only the hippocamppal level of GluR1 in the 15-month mice negatively correlated with swimming distance and positively correlated with the percentage of swimming distance in target quadrant. Conclusion The results suggest that the middle-aged CD-1 mice decrease GluR1 content of hippocampus which correlates with impaired ability of spatial learning and memory,and maternal exposure to inflammation in the late pregnancy accelerate this change.