〔Abstract〕 Objective To investigate the correlation between uterine globulin associated protein 1(UGRP1) and Fas mediated apoptosis pathway in hashimoto thyroiditis(HT). Methods The expression of UGRP1 in thyroid cells of normal people and HT patients was detected by immunohistochemistry(IHC). FRTL-5 cells were transfected by plasmidsin vitro, and control group, UGRP1 group, Fas group were established respectively. Real-time fluorescent quantitative reverse transcription PCR(RT-qPCR) was used to detect the expression of Fas and UGRP1 mRNA in each group. Results UGRP1 expression was positive in thyroid cells of HT patients and negative in that of normal people. There were no significant differences between control group and UGRP1 group in Fas gene expression(1.085 0±0.124 9vs1.021 0±0.113 9). Compared with the control group, the expression of UGRP1 gene increased significantly in Fas group(P<0.000 1, 5.807 0±0.323 2vs0.752 7±0.076 0). Conclusion The high expression of UGRP1 in HT may be related to apoptosis pathway mediated by Fas.