〔Abstract〕 Objective To study the association between single nucleotide polymorphism(SNP) in transcriptional coactivator containing PDZ binding motif(TAZ) gene and the risk of non-cardia gastric cancer. Methods Among 460 patients with non-cardia gastric cancer and 470 normal controls, TAZ rs16861985, rs1055153, rs6783790, rs12490239 were genotyped by polymerase chain reaction-restriction fragment length polymorphism(PCR-RFLP). Unconditional Logistic regression was used to evaluate the association of studied SNPs with the risk of non-cardia gastric cancer. Results TAZ rs16861985 was associated with the risk of non-cardia gastric cancer, compared with the CC genotype carriers, the carriers of GC genotype had an increased risk of non-cardia gastric cancer(OR=1.547, 95%CI: 1.145-2.089). TAZ rs1055153 was associated with the risk of non-cardia gastric cancer, compared with the GG genotype carriers, the carriers of GT+TT genotypes had a decreased risk of non-cardia gastric cancer(OR=0.570, 95%CI: 0.400-0.814). TAZ rs6783790 and rs12490239 were not associated with the risk of non-cardia gastric cancer. Among the haplotypes constructed by TAZ rs16861985, rs1055153, rs6783790 and rs12490239, C-G-A-A haplotype had a decreased risk of non-cardia gastric cancer(OR=0.761, 95%CI: 0.612-0.945), while G-G-A-G haplotype had an increased risk of non-cardia gastric cancer(OR=1.894, 95%CI: 1.314-2.730). The fourth-order interaction of TAZ rs16861985, rs1055153, rs6783790 and rs12490239 was associated with non-cardia gastric cancer risk(P<0.05). Conclusion TAZ rs16861985 and rs1055153 may play a role in the risk of non-cardia gastric cancer. The C-G-A-A haplotype constructed by TAZ rs16861985, rs1055153, rs6783790 and rs12490239 can reduce the risk of non-cardia gastric cancer, and G-G-A-G haplotype can increase the risk of non-cardia gastric cancer. The interaction of TAZ rs16861985, rs1055153, rs6783790 and rs12490239 has a synergistic effect innon-cardia gastric cancer.