〔Abstract〕 Objective To investigate the associations of the single nucleotide polymorphism(SNP) rs2304733 in TEA domain transcription factor 1(TEAD1), rs7135838 and rs1990330 in TEA domain transcription factor 4(TEAD4) genes with the risk of non-cardia gastric carcinogenesis. Methods Enzyme linked immunosorbent assay(ELISA) was used to detect specific antibodies againstHelicobacter pylori(Hp)in serum samples of the normal control group. 470 normal controls were divided into Hp infection negative group(n=223) and positive group(n=247) based on antibody titers. In the 450 non-cardia gastric cancer cases and 470 controls, polymerase chain reaction-restriction fragment length polymorphism(PCR-RFLP) was used to genotype the each SNP locus. The unconditional Logistic regression method was used to evaluate the associations between each SNP locus and the risk of non-cardia gastric carcinogenesis. Results The SNPs of TEAD1 and TEAD4 were not associated with Hp infection. TEAD1 rs2304733 was associated with the risk of non-cardia gastric cancer. Compared with the carriers of TT genotype, the carries of CT and CC genotypes had an increased risk of non-cardia gastric cancer(CTvsTT:OR=2.321, 95%CI: 1.690-3.188; CCvsTT:OR=5.140, 95%CI: 1.080-24.463). TEAD4 rs1990330 was associated with the risk of non-cardia gastric cancer. Compared with the carriers of GG genotype, those with GT genotype had an increased risk of non-cardia gastric cancer(OR=2.405, 95%CI: 1.480-3.908). TEAD4 rs7135838 was not associated with the risk of non-cardia gastric cancer. TEAD1 rs2304733, TEAD4 rs7135838 and rs1990330 had interaction effects on the risk of non-cardia gastric cancer(P<0.05). Conclusion In Baotou Han population, TEAD1 rs2304733 and TEAD4 rs1990330 do not play a major role in Hp infection, but may play a role in the risk of non-cardia gastric cancer. TEAD4 rs7135838 may not play a major role in the risk of Hp infection and non-cardia gastric cancer. TEAD1 rs2304733 and TEAD4 rs1990330 have the strongest synergistic effect on the risk of non-cardia gastric cancer, which is the best interaction model.