〔Abstract〕 Objective To investigate whether miR-19a interacts with insulin-like growth factor 2 receptors(IGF-2R) in infantile hemangiomas(IHs) and affects the proliferation, migration, and adipogenesis of hemangioma stem cells(HemSCs). Methods HemSCs were isolated, screened and cultured from IH specimens. IGF-2R expression in HemSCs was identified using immunohistochemistry. HemSCs transfected with miR-19a mimics and inhibitors were subjected to CCK-8, wound healing, Transwell, qRT-PCR, and Western blot analyses. Results Compared with the control, the proliferation and migration rate of HemSCs treated with miR-19a inhibitors were significantly increased, and overexpression of miR-19a significantly inhibited IGF-2 induced cell migration and proliferation(P<0.05). Conclusion MiR-19a may inhibit HemSCs proliferation, migration, and adipogenesis by targeting IGF-2R.