〔Abstract〕 Objective To explore the difference of serum inflammatory cytokines level in depression patients with non-suicidal self-injury(NSSI),depression patients without NSSI and normal control group, and to analyze the correlation between inflammatory cytokine level and impulsive characteristics of patients in NSSI group. Methods 40 depression patients with NSSI( NSSI group),45 depression patients without NSSI( non-NSSI group) and 40 cases of normal control group were selected, and enzyme-linked immunosorbent assay(ELASA) was used to detect serum IL-2、IL-6、IL-10、IL-15 and TNF-α levels.The Hamilton Depression Scale(HAMD) was used to evaluate the condition.The patient′s impulsivity was evaluated with Barratt Impulsive-ness Scale(BIS-11). Results The levels of serum IL-2、IL-6、IL-10、IL-15 and TNF-α in the NSSI group were significantly higher than those in the non-NSSI group and the normal control group(P<0.01),and the difference was statistically significant.The score of BIS-11 motor impulsiveness, nonplanning impulsiveness and total score in NSSI group were higher than those in non-NSSI group, with statistically significant difference(P<0.01).The levels of serum IL-2、IL-6、IL-10、IL-15 and TNF-α in NSSI group were positively correlated with BIS-11 motor impulsiveness score, nonplanning impulsiveness score and total score. Conclusion The levels of inflammatory cytokines in depression patients with NSSI increase significantly, and the patients have more obvious impulsive personality characteristics.The levels of inflammatory cytokines is positively correlated with the impulsivity of patients.