〔Abstract〕 Objective To observe the dynamic expression of recombinant lysyl oxidase like protein 1(LOXL1) in the lysine oxidase family in the liver of C57BL/6 mice infected withSchistosoma japonicumand explore its role in hepatic fibrosis. Methods Mice were infected subcutaneously with cercariae ofS.japonicum,and sacrificed with euthanasia in 6,9 and 12 weeks after infection. The sera and liver tissues were collected. The levels of liver fibrosis in mice was dynamically evaluated by HE and Sirius red staining, and the serum transaminases were detected. The dynamic expression levels of collagen type Ⅰ( Col1), LOXL1 and α-smooth muscle actin(α-SMA) in liver tissues were determined respectively by Western blot and qPCR. Finally, the dynamic levels of soluble and insoluble collagens were detected. Results The result of HE and Sirius red staining showed that hepatic fibrosis levels increased at 6 weeks, peaked at 9 week, and decreased at 12 week in response toS.japonicum infection. Western blot and q-PCR showed that the expression levels of LOXL1,Col1α1,Col3α1 and α-SMA was significantly up regulated and reached maximum at the 9th week in response toS.japonicuminfection. Soluble collagen protein levels reached maximum at the 9th week. and decreased at 12 week, however insoluble collagen protein levels continued to increase. Conclusion There may be a correlation between LOXL1 and fiber cross-linking in the process of hepatic fibrosis inS.japonicum, and it plays a role in promoting hepatic fibrosis.