〔Abstract〕 Objective To explore the factors associated with the distance from the anal verge to rectal cancer(DAVtRC). Methods 102 patients with rectal cancer provided the clinicopathological data. Two groups of patients were created: low rectal cancer group(LRC) for those with DAVtRCs less than 7cm and mid/high rectal cancer group(M/HRC) for those with DAVtRCs greater than 7 cm. The two groups′ clinical and pathological differences were compared. Quantile regression was used to analyze the associations between DAVtRC and the clinicopathological factors. Results LRC had a lower median DAVtRC(5.00 cm [IQR: 4.00, 6.00 cm]) than that in M/HRC [10.00 cm(IQR: 10.00, 11.00 cm)](P<0.01), but had higher mean monocytes[(0.41±0.16)vs(0.34±0.11),P<0.05]. In the model with continuous and categorical variables at 95% quantile, DAVtRC was negatively associated with age(β=-0.204,P<0.01), TNM stage(Ⅲ+ⅣvsⅠ:β=-6.623,P<0.01), platelet(PLT,β=-0.024,P<0.01), vessel invasion(β=-1.544,P<0.01), but positively associated with BMI(β=0.278,P<0.01), tumor diameters(β=0.548,P<0.01), male(β=1.421,P<0.01), low and middle differentiations(β=4.727,P<0.01), T stage(T2vsT1:β=4.422,P<0.01), N stage(N1vsN0:β=6.670,P<0.01), nerve invasion(β=1.825,P<0.01), carcinoembryonic antigen(CEA,β=0.068,P<0.01), lymphocyte(L,β=3.068,P<0.01), platelet lymphocyte ratio(PLR,β=0.045,P<0.01), lymphocyte monocyte ratio(LMR,β=1.088,P<0.01).Quantile regression curves showed that the coefficients of age, body mass index(BMI), tumor diameter, PLT, PLR and LMR were different in different quantiles of DAVtRC. Conclusion DAVtRC is significantly associated with multiple clinicopathological factors in rectal cancer, but in different quantiles, the coefficients are different.