〔Abstract〕 Objective To investigate risk factors related to coronary artery lesion(CAL) in children with Kawasaki disease. Methods Retrospective analysis was conducted on clinical data of 144 children with Kawasaki disease. The cases were divided into two groups according to whether they had CAL or not. There were 50 children in CAL group and 94 children in non-coronary artery lesion(NCAL) group. The clinical and laboratory indicators in the two groups were analyzed and compared, and the diagnostic efficacy of these indicators for Kawasaki disease combined with CAL was analyzed by drawing the receiver operating characteristic(ROC) curve. Results There was no statistical significant difference in age, gender, duration of fever, use time of immunoglobulin, erythrocyte sedimentation rate, C-reactive protein, serum amyloid A, N-terminal pro brain natriuretic peptide, white blood cell, hemoglobin and platelet between the two groups(P>0.05). In CAL group, the serum levels of 25-(OH)D3and albumin were lower, while the levels of alanine transaminase, interleukin-6 and procalcitonin were higher than those in NCAL group(P<0. 05). Multivariate logistic regression analysis showed that the levels of serum 25-(OH)D3(OR= 0. 984,95% CI: 0. 974 ～ 0. 995),albumin(OR = 0. 857,95% CI: 0. 771-0. 951),alanine transaminase(OR= 1. 011,95% CI: 1. 005-1. 017) and interleukin-6(OR = 1. 002,95% CI: 1. 000-1. 005) were significantly related with coronary artery lesion in children with kawasaki disease(P<0. 05). The levels of 25-(OH)D3,albumin,alanine transaminase and interleukin-6 in serum had diagnostic value for Kawasaki disease combined with CAL,and the area under the curve(AUC) were 0. 660,0. 652,0. 711,and 0. 700,respectively. The AUC of combined diagnosis of four indicators was 0. 816. Conclution Decrease of serum 25-(OH)D3and albumin levels,increase of serum interleukin-6 and alanine transaminase levels in children with Kawasaki disease are risk factors for CAL,combined detection on these multi-indicators have diagnostic value for Kawasaki disease combined with CAL.