〔Abstract〕 Objective To investigate the correlation between CD47 and cervical lesions. Methods The expression and overall survival of CD47 in cervical cancer was analyzed using TCGA and TCGA Target GTEx databases.Based on GEO databases, the expression of CD47 was analyzed between cervical sample infected by HPV 16/18 and non-HPV.The differences of CD47 expression in the degrees of cervical lesions infected by HPV 16/18 were compared.The patholgical sections of colposcopy biopsy came from 320 patients who were admitted cervical cancer screening, including HPV typing and E6/E7 mRNA detection. Immunohistochemistry were used to determine CD47 expression, and histochemistry score(H-score) was used to quantify the levels of CD47.The correlation among HPV 16/18, pathological grades and CD47 was analyzed. Results Bioinformatics tool analysis and immunohistochemistry showed that CD47 was up-regulated in HSIL and CC, associated with the prognosis of CC. The expression levels of CD47 in cervical tissues increased significantly after HPV 16/18 infection(t=2.494, P<0.05), and in HPV 16/18 infected tissues, with the increase of pathological grades.The expression levels of CD47 significantly increased(F=4.351, P<0.05; rs=0.278, P<0.001).The expression of CD47 in the E6/E7 mRNA(+) was higher than that in the E6/E7 mRNA(-)(t=5.710, P<0.000 1), and the copies of E6/E7 were related to the degree of cervical lesions, and were positively correlated with the expression level of CD47(F=15.557, P<0.000 1; rs=0.649, P<0.000 1)(rs=0.73, P<0.000 1). Conclusion CD47 is overexpressed in HSIL and CC after HPV 16/18 infection. The expression levels of CD47 increases with the degree of cervical lesions, and is correlated with E6/E7 mRNA. CD47 may be a potential target for cervical disease progression and therapy.