〔Abstract〕 Objective To study the relationship between the single nucleotide polymorphism of HLA-A rs3132682 and the risk of liver cancer. Methods The author selected 291 cases of liver cancer patients in Yanbian area as the experimental group and 272 healthy people as the control group. The genotypes and allele frequencies of the two loci were detected by MassARRAY SNPS mass spectrometry. Odds ratio(OR) and 95% confidence interval(CI) were calculated by unconditional logistic regression to evaluate the risk of liver cancer in patients with different genotypes. Results There were G and C alleles in HLA-A rs3132682 locus, GG, GC and CC genotype. After adjusting for confounding factors in HLA-A rs3132682 locus, there was correlation between CC genotype and the risk of liver cancer compared with GG genotype(P<0. 05). Stratification analysis showed that compared with the population with CG + GG genotype, the Korean population with CC genotype increased the risk of liver cancer by 3. 331 times.Conclusion The single nucleotide polymorphism ofHLA-Ars3132682 is correlated with the risk of liver cancer in Yanbian area.