〔Abstract〕 Objective To analyze the causal relationship between Sjogren′s syndrome(SS) and primary biliary cholangitis(PBC) and abnormal liver function by two-sample Mendelian randomization. Methods From the genome-wide association study, single nucleotide polymorphisms of SS, PBC, alkaline phosphatase, alanine aminotransferase, aspartate aminotransferase, γ-glutamyltransferase, direct bilirubin and total bilirubin levels were extracted as instrumental variables. Inverse-variance weighted(IVW) analysis was used as the main analysis, supplemented by weighted median, MR-Egger, weighted mode, and simple mode. And a series of sensitivity analyses were carried out to verify the robustness of the results. Results The IVW analysis results of PBC on SS were as follows:P=8.57E-11,OR=1.185 9,95%CI=1.126 4-1.248 5;IVW analysis of PBC on SS(P>0.05). IVW analysis results of SS on alkaline phosphatase were as follows:P=0.041 5,Beta=-0.007 2,95%CI=-0.014 0--0.000 3; IVW analysis results of SS on alanine aminotransferase, aspartate aminotransferase, γ-glutamyltransferase, direct bilirubin, total bilirubin levels showed no statistically significant difference. Conclusion PBC can significantly increase the risk of SS, but SS cannot be proved to have a causal effect on the occurrence of PBC. SS has a potential effect on reducing alkaline phosphatase levels, but it is not proved that SS has causal relationship with alanine aminotransferase, aspartate aminotransferase, γ-glutamyltransferase, direct bilirubin, total bilirubin levels.