〔Abstract〕 Abstract Objective To explore the differences in oxidative stress levels between patients with and without non- suicidal self-injury (NSSI) behavior in depressive disorders , and their correlation with depressive symptoms , dis- ease duration , and self-injury frequency. Methods A total of 95 subjects were included in the study , including 65 patients with depression (patient group) . They were divided into NSSI subgroup (31 cases) and Non-NSSI sub- group (34 cases) based on whether they had NSSI . 30 healthy control group cases( HC) . Enzyme linked immu- nosorbent assay (ELISA) was used to detect the levels of superoxide dismutase (SOD) , catalase (CAT) , malond- ialdehyde (MDA) , glutathione peroxidase(GPX) , and oxidized low-density lipoprotein (OxLDL) in the peripheral blood of the subjects . The Hamilton depression rating scale ( HAMD-17) was used to assess the patient /s condi- tion , and the Ottawa self-injury inventory (OSI) was used to quantitatively evaluate the self-injury frequency of NS- SI group patients . Results The levels of SOD , CAT , MDA , GPX and OxLDL in the patient group were significantly higher than those in the control group (P < 0. 05) . The levels of SOD , CAT , MDA , GPX and OxLDL in the Abstract Objective To explore the differences in oxidative stress levels between patients with and without non- suicidal self-injury (NSSI) behavior in depressive disorders , and their correlation with depressive symptoms , dis- ease duration , and self-injury frequency. Methods A total of 95 subjects were included in the study , including 65 patients with depression (patient group) . They were divided into NSSI subgroup (31 cases) and Non-NSSI sub- group (34 cases) based on whether they had NSSI . 30 healthy control group cases( HC) . Enzyme linked immu- nosorbent assay (ELISA) was used to detect the levels of superoxide dismutase (SOD) , catalase (CAT) , malond- ialdehyde (MDA) , glutathione peroxidase(GPX) , and oxidized low-density lipoprotein (OxLDL) in the peripheral blood of the subjects . The Hamilton depression rating scale ( HAMD-17) was used to assess the patient /s condi- tion , and the Ottawa self-injury inventory (OSI) was used to quantitatively evaluate the self-injury frequency of NS- SI group patients . Results The levels of SOD , CAT , MDA , GPX and OxLDL in the patient group were significantly higher than those in the control group (P < 0. 05) . The levels of SOD , CAT , MDA , GPX and OxLDL in the