〔Abstract〕 Abstract Objective To investigate the distribution of solute carrier organic anion transporter family member 1B1 (SLCO1B1) and apolipoprotein E(ApoE) gene polymorphisms in the patients of Han nationality with cardiovascu- lar and cerebrovascular diseases from Anhui Province , in order to provide the basis for the individualized therapy of statins in clinical practice . Methods 924 Han patients with cardiovascular and cerebrovascular diseases were se- lected . The SLCO1B1 and ApoE genotypes of the patients were detected by polymerase chain reaction-fluorescent probe method , and their distribution was compared among different genders and other regions in China. Results Seven SLCO1B1 gene subtypes were detected in 924 patients , including * 1a/ * 1b (33 . 01% ) , * 1b/ * 1b (41 . 45% ) , *1b/ *15(12. 34% ) , *1a/ *1a(7 . 03% ) , *1a/ *15(5 . 52% ) , *15/ *15(0. 54% ) and * 5/ *5(0. 11% ) , without detection of the two gene subtypes of * 1a/ *5 and *5/ * 15 ; the normal metabolic genotype I of SLCO1B1（ *1a/ *1 a , *1a/ *1b , *1b/ *1b) accounted for the highest proportion in this popu- lation(81 . 49% ) , the intermediate metabolic genotype II and the weak metabolic genotype III of SLCO1B1 accoun- ted for 17. 86% and 0. 65% respectively; six ApoE gene subtypes were detected , including E3/E3 (66. 78% ) , E3/E4(19. 37% ) , E2/E3(9. 63% ) , E4/E4( 1 . 84% ) , E2/E4 (1 . 73% ) and E2/E2(0. 65% ) ; the E3 mass genotype (E2/E4 , E3/E3) accounted for the highest proportion in this population (68 . 51% ) ; there was no sig- nificant difference in the distribution of SLCO1B1 and ApoE genes between different genders; there was no signifi- cant difference in the distribution of SLCO1B1 between the Han population from Anhui and the South China and Central China , but a significant difference was found between the Anhui Han population and the Southwest China ( P < 0. 05) ; the distribution of ApoE in the Anhui Han population demonstrated no statistically significant variation from those in South China and Southwest China , whereas significant differences were observed in comparison with Central China(P < 0. 05) . Conclusion In the Han population with cardiovascular and cerebrovascular diseases in Anhui , the distributions of SLCO1B1 and ApoE gene polymorphisms show no significant gender differences but ex- hibit regional variations . These populations are predominantly characterized by class I normal metabolic genotype (SLCO1B1) and E3 mass genotypes (ApoE) , indicating a higher tolerance to statin dosages and normal therapeu- tic efficacy in this cohort.