〔Abstract〕 Alzheimer ′s disease (AD) is a common neurodegenerative disease . It has been found that AD is re- lated to various pathogenic factors such as genetics , cardiovascular and cerebrovascular disease , and excessive phosphorylation of tau protein . However , no definitive conclusions on its pathogenesis have been reached . In this paper , the research progress on the pathogenesis of AD in C. elegans model and the therapeutic effects of traditional Chinese medicine extracts on AD are reviewed , providing a basis for further research on the alleviating effects of Chinese medicine extracts on AD .