Found programs: Natural Science Foundation of Inner Mongolia Autonomous Region (No.2020MS08075);Innovation Team Development Plan Project of Baotou Medical College(No.bycxtd-14)
Authors：He Shan; Gao Fang; Rong Songhao; Ma Shuyi; Gao Li
Keywords：rectal cancer;ZBED6;single nucleotide polymorphism;unconditional Logistic regression;rs7552670;correlation
DOI：10.19405/j.cnki.issn1000-1492.2025.04.011
〔Abstract〕 Objective To investigate the relationship between the risk occurrence of rectal cancer and the single nucleotide polymorphisms(SNP) of zinc finger protein 6(ZBED6), and to provide the experimental basis for early diagnosis and treatment of rectal cancer. Methods Polymerase chain reaction-restriction fragment length polymorphism(PCR-RFLP) technology was used to genotype the ZBED6 gene in 109 randomly selected rectal cancer patients and 110 unrelated healthy controls. To evaluate the relationship between alleles, genotypes and the risk of rectal cancer, unconditional Logistic regression analysis was used toORand 95%CI. Results The SNP rs7552670 of ZBED6 had significant correlation with the risk of rectal cancer. Compared with the population carrying the TT genotype, those carrying the TC genotype had a 2.653 fold increased risk of rectal cancer(TTvsTC:OR=2.635, 95%CI=1.501-4.690). Other SNPs had no significant correlation with the risk of rectal cancer. Conclusion There is an interaction between the polymorphisms of ZBED6(rs7552670) and rectal cancer. The population carried ZBED6 rs7552670 TC genotype had an growing risk of rectal cancer.