〔Abstract〕 Objective To investigate the effect of vascular endothelial growth factor(VEGF) and clinical features on prognosis of diffuse large B-cell lymphoma(DLBCL). Methods The general data, laboratory and imaging examination, and immunohistochemical staining results of 203 cases of newly diagnosed DLBCL were collected.MaxStat statistics were used to calculate the optimal cut-off points of VEGF, albumin, β2-microglobulin, RBC count, hemoglobin, lactate dehydrogenase and age. Univariable and multivariable analyses were performed using Cox proportional risk model to determine the variables affecting the survival outcome of DLBCL patients.Results The 203 patients included 104 males(51. 2%) and 99 females(48. 8%), with a median age of 59 years, 97 patients(47. 8%) with Ann Arbor stage Ⅲ/Ⅳ, with a median follow-up time of 37. 6 months and a 5-year OS of 62%. There were significant differences in VEGF, age, RBC count, hemoglobin, platelets, albumin, β2-microglobulin, lactate dehydrogenase and fibrinogen between the survival group and the death group(P<0. 05). The optimal cutoff point of VEGF was 266. 8 pg/ml. Univariable and multivariable analyses showed that VEGF, RBC count, hemoglobin and albumin affected the prognosis of DLBCL. Patients with increased VEGF were associated with higher Ann Arbor stage, ECOG score, IPI score, MYC positive and BCL-2 positive expression. In addition,patients with high levels of VEGF in the low-risk IPI group had poorer survival.Conclusion High level of VEGF was associated with poor prognosis of DLBCL patients, and VEGF could perform more accurate stratification for patients with Ann Arbor stage Ⅲ/Ⅳ, ECOG<2 points, IPI low-risk group, BCL-2 negative expression group and MYC positive expression group.