〔Abstract〕 Skin , the largest organ of the human body , serves as the primary barrier against environmental haz- ards . Skin aging is a complex process influenced by both intrinsic factors , such as endogenous physiological chan- ges , and extrinsic factors , including environmental exposures , reflecting the internal health status of the body. Dur- ing skin aging , various cell types exhibit diverse responses to aging-related stimulations . This paper systematically reviews the roles of cells in the pathogenesis of skin aging and explores potential therapeutic strategies for mitigating this process . Furthermore , based on the biological activities of cells during skin aging , we elucidate the interaction mechanisms among cells within the skin microenvironment.