Found programs: Scientific Research Project of the Disease Prevention and Control Center of Xinjiang Production and Construction Corps (No. BTCDCKY202207)
Authors:Bai Maochao1, Wang Yan2, Li Fanka3, Wang Hua4, Guo Yan1, Zhang Hui5
Keywords:Human papillomavirus; high-risk type; age; infection rate ; type of infection; vaginal infectious diseases
DOI:
〔Abstract〕 To investigate the high-risk human papillomavirus (HR-HPV) infection and its relationship with vaginal infectious diseases among women in the region of the Fourth Division of Xinjiang Production and Construction Corps, and to provide a basis for the prevention and control of cervical cancer among women in this region. Methods Uterine exfoliative cells and vaginal secretions were collected from women aged 25-64 years in the resident population (≥6 months of residence) who participated in cervical cancer screening in the Fourth Division of Xinjiang Corps from 2023-2024, and human papillomavirus typing and vaginal microecology tests were performed to compare the status of HPV infections in different age groups. The study subjects were divided into HR-HPV-positive and HR-HPV-negative groups according to whether HR-HPV infection was detected or not, and multifactorial logistic regression analysis was used to explore the relationship between HR-HPV and vaginal infectious diseases. Results The HR-HPV infection rate of women in the Fourth Division of Xinjiang Production and Construction Corps was 10.43%, and the HR-HPV infection rate of each age group was 14.34% from 25 to 34 years old, 10.16% from 35 to 44 years old, 8.70% from 45 to 54 years old, and 11.89% from 55 to 64 years old, and there were differences in the infection rate of HR-HPV among different age groups (P<0.05). Among HR-HPV, HPV52, HPV16, HPV58, HPV51, HPV68 were the most common, with 76.69% of single infections, 18.02% of dual infections, 4.46% of triple infections, and 0.83% of quadruple infections. HR-HPV single infections and multiple infections were prevalent in the age group of 25-34 years old and 55-64 years old.HR-HPV mono-infection and multi-infection rates were statistically different between age groups (P<0.05). The infection rates of bacterial vaginosis (BV) and trichomoniasis vaginitis (TV) were higher in HR-HPV-positive patients (P<0.05). Logistic regression analysis showed that the infection rates of BV (OR=1.560, 95% CI: 1.195~2.035), TV (OR=2.208, 95% CI: 1.221~3.993) were risk factors for HR-HPV infection (P<0.05). Conclusion In the screened population of the Fourth Division of Xinjiang Production and Construction Corps, HR-HPV mono-infection is the most prevalent type. Women aged 25-34 and 55-64 years old show higher rates of HR-HPV infection. The most common HR-HPV genotypes, in descending order, are 52, 16, 58, 51, and 68. BV and TV are the two major risk factors closely associated with HR-HPV infection.