Found programs: National Natural Science Foundation of China (No . 82371495) ; Youth Cultivation Program of The First Affiliated Hospital of Naval Medical University (No . 2021JCQN10)
Authors：Song Chenrui 1 , 2 , Liu Yanqun1 , Bi Xiaoying1
Keywords：idiopathic inflammatory demyelinating disease of the central nervous system; endothelin-1 ; vascular demyelinating diseases of the central nervous system; central nervous system inflammation; disability severity; emo- tional-cognitive function
DOI：10.19405/j.cnki.issn1000-1492.2025.07.022
〔Abstract〕 To examine the relationship between the levels of endothelin-1 (ET-1) and the severity of clinical symptoms in idiopathic inflammatory demyelinating diseases (IIDDs) of the central nervous system . Meth- ods A total of 45 patients with central nervous system demyelinating diseases were enrolled in the study . Among them , 25 patients were diagnosed with idiopathic IIDDs , 20 had vascular demyelinating diseases of the central nerv- ous system , and 10 healthy controls were also included . Serum ET-1 levels were assessed using ELISA , and a fur- ther analysis was conducted to investigate the correlation between these ET-1 levels , laboratory test results , and the degree of disease disability in the IIDDs patient group . Results ① Of the three groups , ET-1 levels were highest in the IIDDs (P < 0. 000 1) . The expression level of ET-1 in the vascular demyelinating disease group was lower than in the healthy control group , but there was no statistical difference . ② Serum ET-1 levels in patients with se- vere EDSS score group in IIDDs were higher than those in patients with mild to moderate EDSS score group (Z = - 3 . 250 , P = 0. 001) . EDSS score was positively correlated with serum ET-1 levels ( rs = 0. 503 , P = 0. 010) , CSF total protein ( rs = 0. 475 , P = 0. 016) , CSF albumin ( rs = 0. 480 , P = 0. 020) , CSF IgG ( rs = 0. 544 , P = 0. 007) , IgA ( rs = 0. 660 , P = 0. 002) and IgM ( rs = 0. 555 , P = 0. 011) levels . ③ There was a positive correla- tion between serum ET-1 levels and CSF IgM levels ( rs = 0. 455 , P = 0. 044) in IIDDs group . Serum ET-1 level showed no significant correlation with peripheral immune reaction (P > 0. 05) . Conclusion Serum ET-1 levels re- flect the severity of clinical symptoms in IIDDs and show no significant correlation with peripheral immune markers , however , exhibit a positive correlation with disease severity and cerebrospinal fluid IgM levels . These findings sug- gest that serum ET-1 levels may indicate the degree of central nervous system inflammation and play an important role in the development and progression of IIDDs .