〔Abstract〕 To investigate the correlation between the pan-immune inflammation value (PIV) and clini- cal and pathological features of primary IgA nephropathy (IgAN) , and to evaluate the clinical significance of PIV in primary IgAN . Methods 200 patients with primary IgAN diagnosed by renal biopsy were selected as the re- search subjects . General information , laboratory indicators , pathologic features of renal biopsy , and calculations of platelet to lymphocyte count ratio(PLR) , neutrophil to lymphocyte count ratio(NLR) , PIV , and other relevant in- dices about patients were collected . According to the median PIV , subjects were divided into low PIV group (PIV ≤194. 81) and high PIV group (PIV > 194. 81) , and the clinical and pathological data of the two groups were compared and analyzed . Using Spearman rank correlation analysis and logistic regression analysis , the relationship between PIV and primary IgAN in terms of clinical and pathological aspects was explored . Results There were sta- tistical significance in age , gender , height , hyperuricemia , hemoglobin , absolute neutrophil count (ANC) , absolute monocytes count , platelet , PLR , NLR , serum uric acid , immunoglobulin G(IgG) , immunoglobulin A(IgA) /com- plement 3(C3) , and fusion degree of the podocyte foot between the two sets (P < 0. 05) . The result of correlation analysis indicated that PIV was positively correlated with ANC , platelet , absolute monocytes count , PLR , NLR , serum creatinine , C3 , serum uric acid , and fusion degree of the podocyte foot , but negatively correlated with IgG , IgA/C3 , IgA/C4 . The degree of podocyte foot process fusion was positively correlated with PIV , ANC , total choles- terol , and 24-hour urinary protein to creatinine ratio , and negatively correlated with albumin(ALB) , IgG , IgA , and IgA/C3 . Logistic regression analysis further indicated that ALB was an independent protective factor for the occur- rence of podocyte foot process fusion in primary IgAN , and PIV was an independent risk factor for the occurrence of podocyte foot process fusion in primary IgAN . Conclusion PIV is closely related to the clinical symptoms and pathological lesions of primary IgAN . ALB is an independent protective factor for the occurrence of podocyte foot process fusion in primary IgAN , and PIV is an independent risk factor for the occurrence of podocyte foot process fu- sion in primary IgAN , which can be used as an auxiliary indicator of clinical and pathological results , providing valuable information for risk assessment and treatment plan formulation of primary IgAN .