Found programs: National Natural Science Foundation of China ( No . 82100270) ; Open Project of The Third Level Laboratory of Traditional Chinese Medicine Pharmacology Research , National Administration of Traditional Chinese Medicine , China Three Gorges University (No . 2023PTCM06)
Authors：Yang Shasha1 , 2 , Mo Lihua1 , 2 , Wang Huibo1 , 2
Keywords：P2X7R; cardiovascular disease; cardiac remodeling; myocardial fibrosis; myocardial hypertrophy; heart failure
DOI：10.19405/j.cnki.issn1000-1492.2025.07.028
〔Abstract〕 Cardiovascular disease is one of the leading causes of death worldwide , and myocardial remodeling is at the core of the development and progression of most cardiovascular diseases . Purinergic ligand-gated ion channel 7 re- ceptor (P2X7R) is a member of the purinergic receptor family , which is expressed in immune cells , cardiac smooth muscle cells , and endothelial cells , and plays an important role in pathological processes related to immune system regulation , neuroprotection , and inflammatory responses . Activation of P2X7R plays an important role in myocardial remodeling , including myocardial fibrosis , myocardial hypertrophy , and heart failure . Therefore , this article reviews the structural and functional properties of P2X7R and its mechanism of action in myocardial remodeling.