Found programs: National Natural Science Foundation Project(Nos.82060518,U1503125);Special Program for Scientific and Technological Development of the Xinjiang Production and Construction Corps(No.2019BC007);Shihezi University Self-Funded Support Project(No.ZZZC202134)
Authors：Wang Le; Li Weixin; Dong Yangliu; Zhao Xian; Zhu Xinli; Zhang Xuechen; Zhe Xiangyi; Pan Zemin
Keywords：cervical cancer; bromodomain protein 4; human papillomavirus16; viral load; MZ1;
DOI：10.19405/j.cnki.issn1000-1492.2025.06.015
〔Abstract〕 Objective To explore the relationship between the replication-associated bromodomain protein 4(BRD4)and human papillomavirus(HPV) 16(HPV16) viral load in cervical squamous cell carcinoma and CINⅠtissues, confirm the effects of BRD4 degradation agent MZ1 on viral load. Methods Thirty HPV16-positive cervical cancer specimens and 30 non-cervical cancer specimens were collected, and the viral load of the samples was detected by real-time fluorescence quantitative PCR, and the expression of BRD4 was analyzed by immunohistochemistry and Western blot. Results The viral load was higher in the samples of cervical cancer group than in the samples of non-cancer group, the difference is statistically significant(P