〔Abstract〕 Objective To investigate the impact of endometriosis on pregnancy and delivery outcomes in patients undergoing single euploid frozen-thawed blastocyst transfer cycles following preimplantation genetic testing. Methods A retrospective analysis was performed on clinical data from patients undergoing frozen-thawed blastocyst transfer after preimplantation genetic testing at the reproductive center of The First Affiliated Hospital of Anhui Medical University. The endometriosis group comprised 84 treatment cycles. After 1 ∶3 propensity score matching, 252 treatment cycles from non-endometriosis patients were included as the control group. General characteristics and clinical outcomes were compared between the two groups. Results There were no statistically significant differences between the two groups in terms of general characteristics, human chorionic gonadotropin(HCG) positive rate, cycle clinical pregnancy rate per cycle, early miscarriage rate, preterm birth rate, live birth rate per cycle, cesarean section rate, delivery weeks, cumulative clinical pregnancy rate, and cumulative live birth rate(all P>0.05). Conclusion Endometriosis may not reduce the pregnancy rate and live birth rate in single frozen euploid blastocyst transfer cycles.