〔Abstract〕 Objective To investigate the role and related mechanisms of IgD on the viability, proliferation, apoptosis, and other functions of Molm-13 cells. Methods Peripheral blood serum was collected from AML patients and healthy controls. The sIgD levels were quantified by ELISA. Forin vitrostudies, Molm-13 cells were treated with varying concentrations of IgD. Cell viability and proliferation were assessedviaCCK-8 assays, CFSE staining, and colony formation assays. Apoptosis rates were determined using an Annexin V/PI apoptosis detection kit. Preliminary exploration of the mechanisms related to IgD-induced proliferation of Molm-13 were analyzed through differential gene analysis. Results Compared with healthy controls, the levels of sIgD in AML patients were significantly elevated(P<0.001). IgD treatment dose-dependently increased Molm-13 cell viability and proliferation(P<0.05), inhibited apoptosis rates(P<0.001). Conclusion IgD promotes the viability and proliferation of Molm-13 cells, and reduces apoptosis.