〔Abstract〕 To investigate the role and related mechanisms of IgD on the viability , proliferation , apopto⁃healthy controls. The sIgD levels were quantified by ELISA. For in vitro studies , Molm ⁃13 cells were treated with colony formation assays. Apoptosis rates were determined using an Annexin V/PI apoptosis detection kit. Prelimi ⁃nary exploration of the mechanisms related to IgD⁃induced proliferation of Molm ⁃13 were analyzed through differenti⁃al gene analysis. Results Compared with healthy controls , the levels of sIgD in AML patients were significantly el⁃evated (P < 0. 001 ) . IgD treatment dose⁃dependently increased Molm ⁃13 cell viability and proliferation ( P