Found programs: National Natural Science Foundation of China ( No . 82160696);Science and Technology Plan Project of Yunnan Province Science and Technology Department (No . 202401AY070001-033)
Authors：Wang Suqin , Tan Jiayan , Li Ya
Keywords：cancer; centromere proteins ; tumor microenvironment; immune evasion; immunosuppression ; meta- bolic reprogramming
DOI：10.19405/j.cnki.issn1000-1492.2025.10.027
〔Abstract〕 Tumor immune escape represents a pivotal determinant of cancer immunotherapy failure . It ’s mechanis- tically linked to immunosuppressive tumor microenvironment ( TME) . The TME comprises tumor cells , immune cells , stromal components and extracellular matrix . These components interact synergistically to suppress antitumor immunity through multiple pathways , thereby promoting immune evasion . As crucial chromosomal stability regula- tors , centromere proteins (CENPs) remodel the TME via multifaceted mechanisms to potentiate immune evasion . This review synthesizes current knowledge on CENPs ’role in tumor immune evasion , offering novel insights for cancer diagnostics and immunotherapy .