〔Abstract〕 To investigate somatization symptoms in adolescents during frequent earthquakes in Hefei, and to explore their correlation with earthquake experiences. Methods A cross-sectional survey was used to select 324 adolescents in Hefei as the survey objects. The self-rating scale of somatization symptoms (SSS) and the exhaustion scale (FIS) were used to evaluate the somatization symptoms and fatigue degree of middle school students, and multivariate logistic regression analysis was used to explore the related factors of somatization symptoms and fatigue among middle school students. Results A total of 324 adolescents were included The overall detection rate of somatization symptoms was 6.5%, and the detection rate of moderate or above fatigue was 20.1%. The results of regression analysis showed that adolescents who were concerned about the earthquake for a longer time (≥1 h) had a higher risk of somatization symptoms (OR=5.430, 95%CI: 1.547-19.058), and adolescents who received pre-earthquake training had a lower degree of fatigue (OR=0.473, 95%CI: 0.270-0.829) (P<0.05).