Found programs: National Natural Science Foundation of China (No . 81801317) ; Natural Science Foundation of Anhui Province (No . 1808085QH277) ; Natural Science Research Project of Anhui Educational Committee ( No . 2022AH050752)
Authors：Zhang Yuan1 , Xu Yue1 , Zhu Yong2 , Zhang Pingping1
Keywords：TIPE3; colorectal cancer; immune infiltration; prognosis; tumor tissue; tumor normal tissue;
DOI：10.19405/j.cnki.issn1000-1492.2025.11.024
〔Abstract〕 Objective To investigate the expression of TIPE3 in colorectal cancer(CRC) and its correlation with tumor immune infiltration and prognosis.Methods The expression of TIPE3 in tumor and adjacent normal tissues from 110 CRC patients was detected using real-time fluorescence quantitative enzyme chain reaction(qPCR),Western blot,immunohi stochemi stry(IHC),bioinformatics analysis,and single-cell RNA sequencing(scRNAseq).The association between TIPE3 expression and clinicopathological factors,prognosis,and immune cell infiltration was analyzed.Results Transcriptomic and proteomic analyses revealed that among the TIPE family,TIPE(P