〔Abstract〕 Objective To explore the vascular endothelial injury in male mice caused by exposure to polystyrene microplastics（PS-MPs）and the intervention effect of luteolin on vascular remodeling. Additionally，to investigate the mechanism through the oxidative system and metabolomics. Methods Thirty-two C57BL/6 mice（6-8 weeks old）were randomly divided into the saline group（saline group），the 0. 1 mg/kg PS-MPs exposure group（0. 1PS- MPs group），the 1 mg/kg PS-MPs exposure group（1PS-MPs group），and the 1 mg/kg PS-MPs + luteolin treatment group（1PS-MPs + Lut group），with 8 mice in each group. After 8 weeks of intervention，the body weight，blood pressure，aortic organ coefficient，and aortic histopathological changes of mice in each group were detected；the to_tal cholesterol（TC）， triglyceride（TG）， and high-density lipoprotein cholesterol（HDL-C）lipid metabolism-related indicators in the aorta of mice were detected；the reactive oxygen species（ROS），glutathione（GSH），and malondialdehyde（MDA）oxidative stress-related indicators were detected；the endothelin（ET-1）， nitric oxide （NO）， vascular endothelial growth factor A（VEGF-A）， vascular cell adhesion molecule-1（VCAM-1/CD 106）， and intercellular adhesion molecule-1（ICAM-1/CD54）endothelial function-related indicators and serum metabolo_ mics were detected. Results Compared to the saline group，exposure to PS-MPs resulted in pathological thicken_ing of the mouse aorta，increased aortic organ coefficient，and elevated blood pressure. Lipid metabolism-related indicators，including TC and TG，were elevated，while HDL-C was reduced，indicating lipid metabolism disorder in mice. Oxidative stress markers such as ROS and MDA increased，whereas GSH decreased，demonstrating oxidative damage. Vascular endothelial inflammation and injury markers，including ET-1，VEGF-A，VCAM-1，and ICAM-1，were upregulated，while the vasodilatory substance NO was downregulated，confirming endothelial injury. Furthermore，serum metabolomics results revealed that PS-MPs exposure induced endothelial damage by disrupting metabolic pathways such as the citrate cycle. Compared to the PS-MPs group，luteolin significantly reversed these effects，attenuating oxidative stress and lipid metabolism disorders，and effectively repairing endothelial injury. Conclusion PS-MPs induce vascular toxicity through oxidative stress and lipid metabolism. Luteolin effectively alleviates endothelial damage and vascular remodeling.