〔Abstract〕 Objective To evaluate the effect and mechanism of the arterial perforators layered skin flap in repair and treatment of various deep surface wounds. Methods 90 patients with deep wounds were randomly divided into the artery perforators layered flap group and traditional flap group, the former were repaired with prominent arterial perforators layered skin flaps, the latte were repaired with traditional flaps.The differences in length of stay, treatment cost, patient satisfaction at discharge, daily living ability, primary wound healing rate, incidence of complications, wound recurrence rate, and total good rate of wound healing between the two groups were observed. Results Compared with the traditional flap group, arterial perforator layered flaps group had advantages in primary wound healing rate, complication rate and total excellent and good rate, and the difference was statistically significant(P<0.05).There was no significant difference in wound recurrence between the two groups(P>0.05).Compared with traditional flap group, the treatment costs, length of hospital stay, living ability score and patient satisfaction of artery perforators layered flap group had advantages with statistically significant difference(P<0.05). Conclusion Arterial perforators layered flap is an ideal measure to repair deep body surface wounds.It is very important to design layered skin flap according to the principle of individualization.Adequate preparation of wounds, exquisite surgical operation and careful management of post-operation are the guarantee of deep wounds' recovery.