〔Abstract〕 Objective To explore the impact of geriatric nutritional risk index(GNRI) and clinical features on prognosis of patients with diffuse large B-cell lymphoma(DLBCL) based on multicenter data.Methods 505 DLBCL patients diagnosed in 7 medical centers of Huaihai Lymphoma Working group from October 2009 to April 2021 were selected. MaxStat was used to determine the best cut-off value of GNRI. After 1 ∶ 1 propensity score matching(PSM)to balance the covariates between groups,the differences of baseline characteristics and overall survival(OS)between two groups before and after matching were compared. Cox proportional hazards model were used for univariate and multivariate analysis. Kaplan Meier analysis was used to calculate the survival rate and draw the survival curve. Log rank test was used to compare the differences between groups.Results The median age of patients including 273(54. 1%) males was 68 years old. The median survival time was 62. 9 months. Multivariate analysis demonstrated that GNRI,age,LDH and Ann Arbor stage were independent influencing factors of DLBCL(P<0. 05). The best cut-off value of GNRI was 99 based on MaxStat. After PSM,a total of 102 patients in GNRI<99 group could be propensity matched to GNRI ≥99 patients, creating a group of 204 patients. Subgroup analysis showed that GNRI could accurately stratify patients in BCL-2 negative group,BCL-6 positive group,CD5 positive and negative groups,Ann Arbor（Ⅲ-Ⅳ）group and IPI(HIR + HR)group.Conclusion The prognosis of DLBCL is influenced by GNRI,age,LDH and Ann Arbor stage. GNRI has a certain value in evaluating the prognosis of DLBCL patients,and the patients with GNRI≥ 99 indicates a good prognosis.