〔Abstract〕 Objective To investigate the influencing factors of the diffusion and utilization of technology for liver cancer screening among clinicians based on the technology acceptance model. Methods A multi-stage sampling method was applied to select the respondents. The des-γ-carboxy prothrombin(DCP) detection technology was taken as an example to conduct a structured questionnaire survey, and structural equation modeling was used for data analysis. Results Perceived ease of use positively affected perceived usefulness(β=0.899, P<0.001) and usage attitude(β=0.223, P<0.05); perceived usefulness positively affected usage attitude(β=0.652, P<0. 001) and behavioral intentions （β = 0. 413,P<0. 001）; usage attitude positively affected behavioral intentions（β = 0. 511,P<0. 001）; behavioral intention positively affected the behavior of using DCP （ β = 0. 237,P<0. 01）. There was a partial mediating effect between perceived ease of use and usage attitude, and a partial mediating effect between perceived usefulness and behavioral intention.Conclusion Usage attitudes are important factors influencing the diffusion of DCP detection technologies, and usage attitudes are determined by both perceived usefulness and perceived ease of use. It is recommended that technology manufacture and utilization organizations should focus on technology performance, allocate technical advisers for promoting new technologies, and reduce barriers to their use.