〔Abstract〕 Objective To explore the correlation between α 1-antitrypsin, CXCL12, IL-15 Ralpha and the prognosis of HIV-infected patients. Methods A total of 154 HIV-infected patients were selected, and 154 healthy volunteers were randomly selected from our hospital for physical examination and divided into control group.According to the stage of the disease, the patients were divided into stage I, stage II, stage Ⅲ and stage Ⅳ. Western blot was used to detect the expression of α 1-antitrypsin and CXCL12, PC-PCR was used to detect the expression of IL-15 Rα, and indirect method was used to detect the levels of CD3 and CD4. Results Compared with the control group, the levels of CD4 and CD8 in AIDS group decreased abnormally, and the difference was statistically significant(P<0.05); compared with the control group, the expression of α 1-antitrypsin, CXCL12, IL-15 Rα in AIDS group increased(P<0.05); compared with stage I patients, the expression of α 1-antitrypsin, CXCL12, IL-15 Rα in patients with stage Ⅱ increased(P<0.05); compared with stage Ⅱ patients, the expression of α 1-antitrypsin, CXCL12, IL-15 Rα increased(P<0.05); compared with patients in stage Ⅲ, the expression of α 1-antitrypsin, CXCL12 and IL-15 Rα in patients with stage Ⅲ was higher(P<0.05); compared with patients in stage III, the expressions of α 1-antitrypsin, CXCL12 and IL-15 Rα in patients with stage IV increased(P<0.05). Conclusion α 1-antitrypsin, CXCL12 and IL-15 Rα are closely related to HIV infection and prognosis of HIV infected patients.