〔Abstract〕 Objective To explore the effect of sodium aescinate(SA) on hepatic fibrosis induced by bile duct ligation. Methods 54 male SD rats were randomly divided into 3 groups.Rats in the control group(Sham) were only given equivalent normal saline(NS) injection each day after laparotomy.Rats in obstructive jaundice group(OJ group) were only given equivalent NS injection each day after operation. Rats in SA group were given SA injection at the dose of 3.6 mg/kg each day after operation.There were 18 rats in each group.The expression of alanine aminotransferase(ALT),aspartate aminotransferase(AST), total bilirubin(TBIL) was detected by ELISA.The changes of morphological structure and the collagen fiber of rats' liver were revealed by HE and Masson staining. The expression of collagen Ⅰ and collagen Ⅲ was detected by immunofluorescence. The expression of P-4 EBP1、eIF-4 E was detected by immunohistochemical and Western blot analysis. Results In OJ group, the structures of liver were disordered, the expression level of ALT,AST and TBIL in SA group significantly increased, the expression level of collagen Ⅰ and collagen Ⅲ significantly increased, and the expression of eIF-4 E and P-4 EBP1 in hepatocytes decreased.Compared with OJ group, the expression levels of ALT,AST and TBIL in SA group significantly decreased, the expression levels of collagen Ⅰ and collagen Ⅲ significantly decreased, and the expression of eIF-4 E and P-4 EBP1 in hepatocytes increased. Conclusion SA can reduce liver fibrosis by promoting the phosphorylation of 4 EBP1 and activating the expression of eIF-4 E to protect liver cells.